The Oeffinger laboratory studies the regulation and dynamics of RNA maturation pathways. The main focus is to determine the temporal and spatial assembly and coordination of RNA maturation factors, as well as to identify the underlying control mechanisms that drive the processing, modification, and assembly of different RNAs. We, therefore, combine proteomic, RNomic, biochemical and computational approaches to build a dynamic picture of RNA maturation pathways in different cellular contexts and organisms to yield important information on how RNA maturation is linked to other cellular processes including DNA damage and repair, development as well as onset of various neurodegenerative diseases such as Alzheimer’s Disease and ALS, and how different mRNAs may require niche-ribosomes (’specialized ribosomes’) for their optimal, e.i. tissue-specific, translation.
We are located at the Institut de recherches cliniques de Montréal (IRCM) and are affiliated with the département de biochimie et médicine moléculaire at the Université de Montréal and the Department of Experimental Medicine at McGill University. Our work is funded by the Canadian Institutes of Health Research (CIHR), Natural Sciences and Engineering Research Council of Canada (NSERC), Brain Canada/ALS Canada, and the Canada Foundation for Innovation (CFI). We are part of the Integrated Quantitative Bioscience Initiative (IQBI).