Publications

@ IRCM

27. Scott DD, Trahan C, Aguilar LC, Delubac M, Adivarahan S, Van Nostrand E, Zindy PJ, Wei KE, Yeo G, Zenklusen D and  Oeffinger M. Nol12 is a multifunctional endonuclease at the nexus of RNA and DNA metabolism. Nucl. Acids Res. (2017) In Press.

26. Burlacu E, Lackmann F, Aguilar LC, van Nues R, Hector RD, Whiteley ND, Cockroft SL, Wieslander L, Oeffinger M and Granneman S. High-throughput RNA structure probing reveals critical folding events during early stages of 60S ribosome biogenesis in yeast. Nature Comm. 2017 Sep 28;8(1):714. PubMed PDF

25. Vakiloroayaei A, Shah N, Oeffinger M and Bayfield MA. The RNA chaperone La promotes pre-tRNA maturation via indiscriminate binding of both native and misfolded targets. Nucl. Acids Res. 2017 EPub Aug 31; https://doi.org/10.1093/nar/gkx764

24. Milek M, Imami K, Mukherjee N, de Bortoli F, Zinnall U, Hazapis O, Trahan C, Oeffinger M, Heyd F, Ohler U, Selbach M and Landthaler M. DDX54 regulates transcriptome dynamics during DNA damage response. Genome Research 2017 Aug;27(8):1344-1359. EPub June 8; PubMed PDF 

23. Reimer KA, Stark MA, Aguilar LC, Stark SR, Burke RD, Moore J, Fahlman RP, Yip CK, Kuroiwa H, Oeffinger M and Rader SD. The sole LSm complex in Cyanidioschyzon merolae associates with pre-mRNA splicing and mRNA degradation factors. RNA 2017 June; 23: 952-967. EPub March 21; PubMed PDF 

22. Oeffinger M. Moulding the ribosome. Nature 2016 Sept 1; 537(7618):38-39. Nature PubMed 

21. Scott DD and Oeffinger M. Nucleolin and Nucleophosmin: nucleolar proteins with multiple functions in DNA repair. Biochem Cell Biol. 2016 Oct;94(5):419-432. PubMed PDF

20. Scott DD, Trahan C, Zindy PJ, Aguilar LC, Delubac M, Wei KE, and Oeffinger M. Nol12 is a multifunctional endonuclease at the nexus of RNA and DNA metabolism. bioRxiv 2016 doi:http://dx.doi.org/10.1101/043935 bioRxiv PDF

20. Trahan C and Oeffinger M.  Targeted cross-linking-mass spectrometry determines vicinal interactomes within heterogeneous RNP complexesNucl. Acids Res. 2016 Feb; 44(3): 1354-69. EPub 2015 Dec 10. PubMed PDF 

19. Bensidoun P,  Raymond P, Oeffinger M and Zenklusen D. Imaging single mRNAs to study dynamics of mRNA export in the Yeast S. cerevisiae. Methods 2016 Apr 1;98:104-14. Epub 2016 Jan 16. PubMed PDF

18. Trahan C, Aguilar LC and Oeffinger M. Single-Step Affinity Purification (ssAP) and Mass Spectrometry of Macromolecular Complexes in the Yeast S. cerevisiae. Methods in Mol Biol – Yeast Functional Genomics 2016 Jan 1361: 265-87PubMed  PDF

17. Saroufim MA, Bensidoun P, Raymond P,  Rahman S, Krause MR, Oeffinger M and Zenklusen D.  The nuclear basket mediates perinuclear mRNA scanning in yeast.         J Cell Biol. 2015 Dec 21; 211 (6): 1131-40. PubMedPDF

16. Oeffinger M and Montpetit B. Emerging properties of nuclear RNP biogenesis and export. Curr Opinion Cell Biol. – Special Issue Cell Nucleus 2015 June; (34): 46-53. Epub 2015 May 1.PubMed 

15. Fridy PC, Li Y, Keegan S, Thompson MK, Nudelman I, Scheid JF, Oeffinger M, Nussenzweig MC, Fenyö D, Chait BT, and Rout MP.  Rapid production of versatile nanobody repertoires. Nature Methods. 2014 Dec;11(12):1253-60.Epub 2014 Nov 2. PubMed 

14. Bretes H, Rouviere JO, Leger T, Oeffinger M, Devaux F, Doye V and Palancade B. Sumoylation of the THO complex regulates the biogenesis of a subset of mRNPs. Nucl. Acids Res. 2014 Feb; 43(2). Epub 2014 Feb 5. PubMedPDF

13. Oeffinger M. Two Steps Forward – One Step Back: Advances in Affinity Purification Mass spectrometry of Macromolecular Complexes. Proteomics. 2012 May;12(10):1591-608. Review. PubMedPDF

12. Oeffinger M and Zenklusen D. To The Pore and Through The Pore: A Story of mRNA Export Kinetics. Biochim Biophys Acta. 2012 June;1819(6):494-506. Review. PubMedPDF

11. Oeffinger M. Joining the interface: a site for Nmd3 association on 60S subunits.     J Cell Biol. 2010 June 28; 189 (7): 1071-1073.  PubMedPDF

@ Rockefeller University

10. Oeffinger M, Zenklusen D, Wei KE, Ferguson A, El Hage A, Tollervey D, Chait BT, Singer RH and Rout MP. Rrp17p is a eukaryotic exonuclease required for 5’ end processing of pre-60S ribosomal RNA. Mol Cell. 2009 Dec 11; 36 (5): 768-81PubMed PDF

9. Oeffinger M, Wei KE, Rogers R, DeGrasse JA, Chait BT, Aitchison JD and Rout MP. Comprehensive analysis of diverse ribonucleoprotein complexes. Nature Methods. 2007 Nov; 4(11): 951-6. Epub 2007 Oct 7.PubMed

8. Zhang J, HarnpicharnchaiP, Jakovljevic J, Tang L, Guo Y, Oeffinger M, Rout MP and Woolford JL, Jr. Assembly factors Rpf2 and Rrs1 recruit 5S rRNA and ribosomal proteins rpL5 and rpL11 into nascent ribosomes. Genes Dev. 2007 Oct 15; 21(20): 2580-92. PubMedPDF

7. Oeffinger M, Fatica A, Rout MP and Tollervey D. Yeast Rrp14p is required for ribosomal subunit synthesis and for correct positioning of the mitotic spindle during mitosis. Nucl. Acids Res. 2007 March 28; 35(4): 1354-1366. Epub 2007 Feb 1. PubMedPDF

6. Tackett AJ, DeGrasse JA, Sekedat MD, Oeffinger M, Rout MP, and Chait BT. I-DIRT, a general method for distinguishing between specific and nonspecific protein interactions. J Proteome Res. 2005 Sep-Oct; 4(5): 1752-6. Epub 2005 Aug 25. PubMed

@ University of Edinburgh/Wellcome Trust Center

5. Oeffinger M, Dlakic M and Tollervey D. A pre-ribosome associated HEAT-repeat protein mediates export of both ribosomal subunits. Genes Dev. 2004 Jan 15; 18(2): 196-209. Epub 2004 Jan 16. PubMedPDF

4. Oeffinger M, and Tollervey D. The RNA-binding protein Nop15p is required for processing during 60S maturation and cell cycle progression. EMBO J. 2003 Dec 22; (24): 6573-83. PubMed PDF

3. Factica A, Oeffinger M, Tollervey D and Bozzoni I. Cic1p/Nsa3p is required for synthesis and export of 60S ribosomal subunits. RNA 2003 Dec; 9(12): 1431-36. PubMed PDF

2. Fatica A, Oeffinger M, Dlakic M and Tollervey D. Nob1p is required for cleavage of the 3’end of the 18S rRNA. Mol Cell Biol. 2003 Mar; 23(5): 1798-807. PubMedPDF

1. Oeffinger M, Leung A, Lamond A and Tollervey D. Yeast Pescadillo is required for multiple activities during 60S ribosomal subunit synthesis. RNA 2002 May; 8(5): 626-36. PubMedPDF