Ribosomes are the translation machinery and essential to every cell. It has long been assumed that all ribosomes within a cell were identical, however, recent studies suggest that there exist populations of heterogeneous ribosomes within individual cells and across different tissues that differ in their composition and which affects their translational output and regulation. Heterogenous been also been implicated in tissue-specific diseases (ribosomopathies), blocks in stages of development and other pathologies. We are interested in how different conserved ribosomal RNA isoforms (i.e., 5.8S short vs long rRNA) affect ribosome composition, function and output  in the yeast S.cerevisiae and human cells and different tissues.

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