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Ribosomes and neurodegenerative disease
We are studying several links between RNA and disease development such as the role of paraspeckles components in ALS, and the role of RNA oxidation in the onset of Alzheimer’s Disease.
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RNA Binding Proteins & genome integrity
A growing number of RBPs have been identified as part of DNA repair pathways. We are trying to understanding the role of RBPs in genome integrity and maintenance of cell homeostasis in more detail.
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Messenger RNA maturation and export
We are determining the existence of different RNA maturation pathways comprised of subsets of proteins as well as a specialized export route for pre-ribosomes, using proteomic and RNomic approaches.
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What regulates ribosomal DNA damage repair?
We are using crosslinking-MS approaches and computational modelling to gain a more comprehensive picture of intra-complex protein interactions in different RNPs.
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Ribosome Plasticity & Heterogeneous Ribosomes
Recent studies revealed heterogeneous populations of ribosomes. We are interested in uncovering parallel maturation pathways and the role of specialized ribosomes in yeast and human.
Oeffinger Lab 